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JWH-018 is a synthetic cannabinoid receptor agonist with a strong affinity for the CB1 and CB2 receptors (EC50 = 102 nM and 133 nM, respectively)1. Binding to the receptors triggers a reduction of intracellular cAMP levels by inhibition of adenylate cyclase.

In vivo studies on experimental mouse models showed similar responses as THC, including hypothermia, catalepsy, and hypolocomotor effects2.

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In vitro, JWH-018 impaired electrically-induced synaptic transmission as well as LTP and glutamate/GABA release in ex vivo hippocampal slices. All behavioural and neurochemical effects could be prevented by pre-treatment with a CB1 receptor antagonist3.

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